I've said it before and I'll say it again, the American Revolution is one of, if not the, most important events regarding governance since the fall of the Republic. (If you don't know which republic I'm talking about you shouldn't even post in this thread) As such the philosophy and ideals of the men responsible are of import to us.
As a whole the ideals laid out in the Declaration of Independence, Federalist Papers, and in the Constitution are not meant to be addressed to a specific issue, or time, but are the kind of ideals that last millenia. We write specific laws to deal with specific things, these laws are based on our interpretation of those ideals. The changing laws of suffrage in the United States are an example of how we have interpreted an Ideal differently over time, and passed specific laws as a result.
My point is while the Founder's themselves are only significant from a historical perspective, as men who fought and died for ideals they believed in, ideals we still try to live by today, trying to determine what they would say in regards to applying those ideals to our modern society is an act which is as good as trying to determine what the ideals would say themselves, if personified.