What is meaning? What creates it? I guess the answer others have given is correct, but i think they missed the point, your question suggests that there should be an answer. Why? Look at the question in more depth, and ask yourself what is meaning?
I think we create meaning, in which case we create meaning in our lives, and the answer 'to find meaning for your life' is pretty good. We also create religion, and this is a source of meaning, so the answer "Man's chief end is to glorify God, and to enjoy him forever." is pretty good.
The other answer, 'there is no inherent meaning' is also true, if we don't have meaning until we create it.
And the biological answer is factually accurate, things which exist are tue ones which are good at continuing to exist; so in some sense we are fundamentally programmed to act like robots who reproduce, BUT we are also fundamentally programmed to create meaning and act on that, because it turns out that our culture has moved to a point where pure breeding rates is not the only important factor to consider for survival, as either an individual or species.
Ipso facto, all or the above.